If you're coming from the east on I-70 you'll see construction right at downtown Indianapolis.
Don't worry, this is a route that's difficult to screw up.
EASIEST- From I-70 Westbound, exit I-65 North to Chicago:
Once you take the exist, you have two options:
Next post will be the alternate route: Taking I-65 South. It's not open all the way, but it does get to downtown.
Wow, the first post formatted funny...
Anyway, ALTERNATE ROUTE:
The exit to I-65 South looks closed, but there's a lane open on the left of I-70 West for people going downtown. The exit should either be labeled "Ohio. St." or "Michigan St" and have a small "Downtown only" sign added.
So even if you somehow miss the I-65 North exit, you'll still be able to get where you need to go. In fact, you'll have no choice because construction has closed most of that part of the interstate and forces you to exit.
The drawback is that you end up on Michigan Street, north of Monument Circle and blocks away from the Convention Center.
That's not bad though. In the past when I've been in Indy, I've walked from Michigan St. to the mall or hotels near the Convention Center.
If you are heading west on Michigan street, one of the upcoming streets will be your next left turn, depending on which hotel you're in:
That is incredibly detailed and useful information.
You're welcome! Hope it helps!